Exogenous IL-7 Increases Recent Thymic Emigrants in Peripheral Lymphoid Tissue without Enhanced Thymic Function Running Title: IL-7 Alters RTE Homeostasis
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Word Count: 197 Total Text Word Count: 4989 Scientific Heading: Immunobiology Blood First Edition Paper, prepublished online May 6, 2004; DOI 10.1182/blood-2003-10-3635 Copyright (c) 2004 American Society of Hematology For personal use only. on October 3, 2017. by guest www.bloodjournal.org From
منابع مشابه
Exogenous IL-7 increases recent thymic emigrants in peripheral lymphoid tissue without enhanced thymic function.
Interleukin 7 (IL-7) is critical in maintaining thymic-dependent and thymic-independent pathways of T-cell homeostasis. T-cell receptor (TCR) rearrangement excision circles (TRECs) have been used as markers for recent thymic emigrants (RTEs) in assessing human thymic function. To study the thymic and peripheral effects of IL-7 on RTEs, we measured TREC content and peripheral naive T-cell subset...
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Cytokines play a crucial role in the maintenance of polyclonal naive and memory T cell populations. It has previously been shown that ex vivo, the IL-7 cytokine induces the proliferation of naive recent thymic emigrants (RTE) isolated from umbilical cord blood but not mature adult-derived naive and memory human CD4(+) T cells. We find that the combination of IL-2 and IL-7 strongly promotes the ...
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